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Youth prescribing rose fiftyfold, and 62% stopped within a year

Danish registries caught the whole arc in one dataset: rapid adoption among 12-to-24-year-olds, and most of them off it twelve months later.

Wesley Jenkins6 min read
New users per 100,000, Denmarkages 18-2413686ages 12-171.772Still on a prescription after one year:38%Universal healthcare, registry data — not the US cash market.

Prescribing data for young people is scarce, and Denmark’s registries make it available in a way few countries can match. This study covers everyone aged 12 to 24 who filled one of these prescriptions over seven years [1]. The perinatal version of the same rapid-adoption picture is in perinatal prescribing rose thirtyfold.

Growth was extraordinary. Overall use rose more than 50-fold to 418 new users per 100,000 by 2025 — noting that is per hundred thousand, so under half a percent of the age group. The steepest climb was among 18-to-24-year-olds, from 13 to 686 per 100,000; among adolescents aged 12 to 17 it went from 1.7 to 72. Most users were female and few had diabetes.

Two findings point at the same gap. A third of these young users had a psychiatric comorbidity, particularly emotional and neurodevelopmental disorders, and 78% of treatments were initiated in general practice rather than by a specialist. The authors call for specialist involvement, long-term safety data and careful evaluation of mental health in this group — which is a statement about monitoring rather than a claim that harm occurred.

The transfer to a cash market is where care is needed. Denmark has universal healthcare and prescriptions linked to national registries, so “initiated in general practice” means a doctor who holds the patient’s record. A young person buying through a telehealth seller has no such relationship, and the 38% persistence figure describes people whose prescriptions were at least being tracked. What the same pattern looks like when nobody is tracking is the subject of two thirds stop within a year.

For a parent or a young buyer the practical reading is about the shape of the commitment rather than the drug. Most people this age who start do not continue past a year, and weight returns when treatment stops — so the question worth asking before the first payment is what the plan is for month thirteen. The cost side of that is in what a GLP-1 actually costs and the two regain numbers.

Frequently asked

How many young people stay on these drugs?
In this Danish cohort, 38% of new users aged 12 to 24 were still covered by a prescription after one year, meaning roughly three in five had stopped.
How common is it in that age group?
By 2025, 418 new users per 100,000 — under half a percent of the age group — after more than a fiftyfold rise since 2018.
Who is prescribing it?
Mostly general practice: 78% of new treatments were initiated there rather than by a specialist, and the authors call for greater specialist involvement given that a third of users had psychiatric comorbidity.

Sources

  1. [1] Kildegaard H, Andersen JH, Vinding RK, Kloppenborg JT, Pottegård A (2026). Use of Glucagon-Like Peptide-1 Receptor Agonists in Danish Adolescents and Young Adults 2018-2025 Obesity (Silver Spring, Md.). PMID 42252120

Where to get it

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